Search results for " c.c."

Augmented reality based middle and inner ear surgical procedures

2020

Otologic procedures involve manipulation of small, delicate and complex structures in the temporal bone anatomy which are in close proxmity of critical nerves and blood vessels. Augmented reality (AR) can highly benefit the otological domain by providing supplementary anatomical and navigational information unified on a single display. However, despite being composed of mainly rigid bony structures, the awareness and acceptance of possibilities of AR systems in otology is fairly low. This project aims at developing video-based AR solutions for middle and inner ear surgical procedures.We propose two applications of AR in this regard. In the first application, information about middle ear cle…

La nueva definición de seguridad

2002

La moral en la economía de mercado

2000

Identification and Experimental Validation of an Induction Motor Thermal Model for Improved Drivetrain Design

2017

The ability of an electric powertrain to perform according to mechanical specifications is equally important as assessing its thermal protection limits, which are affected by its electrical and thermal properties. Although rated parameters (such as power, torque, etc.) are easily accessible in catalogs of equipment producers, more specific properties like mass/length of copper winding, heat dissipation factor, etc., are not available to customers. Therefore, an effective selection of drivetrain components is limited due to the lack of sufficient data and the need to consult critical design decisions with suppliers. To overcome this limitation, we propose a method to estimate the temperature…

Persistent inflammation alters the function of the endogenous brain stem cell compartment

2008

Endogenous neural stem/precursor cells (NPCs) are considered a functional reservoir for promoting tissue homeostasis and repair after injury, therefore regenerative strategies that mobilize these cells have recently been proposed. Despite evidence of increased neurogenesis upon acute inflammatory insults (e.g. ischaemic stroke), the plasticity of the endogenous brain stem cell compartment in chronic CNS inflammatory disorders remains poorly characterized. Here we show that persistent brain inflammation, induced by immune cells targeting myelin, extensively alters the proliferative and migratory properties of subventricular zone (SVZ)-resident NPCs in vivo leading to significant accumulation…

In vitro fusion of phagosomes with different endocytic organelles from J774 macrophages.

1998

We describe novel biochemical and electron microscopy assays to investigate in vitro fusion of latex bead phagosomes with three different endocytic organelle fractions from J774 macrophages. After formation, early phagosomes fuse avidly with early and late endosomes and for a longer period of time with lysosomes, but they subsequently become fusion-incompetent. The fusion of early, but not late, phagosomes with all three endocytic fractions could be significantly stimulated by Rab5. In contrast to other cell types investigated, this Rab is uniquely enriched on both early and late endosomes in J774 macrophages. Moreover, exogenous Rab5 stimulates homotypic fusion between both sets of organel…

Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts.

2006

Alterations in the number and/or morphology of centrosomes are frequently observed in human tumours. However, it is still debated if a direct link between supernumerary centrosomes and tumorigenesis exists and if centrosome amplification could directly cause aneuploidy. Here, we report that hydroxyurea treatment induced centrosome amplification in both human fibroblasts expressing the HPV16 -E6-E7 oncoproteins, which act principally by targeting p53 and pRB, respectively, and in conditional pRB deficient mouse fibroblasts. Following hydroxyurea removal both normal and p53 deficient human fibroblasts arrested. On the contrary pRB deficient fibroblasts entered the cell cycle generating aneupl…

Revising midlatitude summer temperatures back to A.D. 600 based on a wood density network

2015

Annually resolved and millennium-long reconstructions of large-scale temperature variability are primarily composed of tree ring width (TRW) chronologies. Changes in ring width, however, have recently been shown to bias the ratio between low- and high-frequency signals. To overcome limitations in capturing the full spectrum of past temperature variability, we present a network of 15 maximum latewood density (MXD) chronologies distributed across the Northern Hemisphere extratropics. Independent subsets of continental-scale records consistently reveal high MXD before 1580 and after 1910, with below average values between these periods. Reconstructed extratropical summer temperatures reflect n…

Cecal trap: CT findings of isolated cecal necrosis

2016

Learning objectives Background Findings and procedure details Conclusion Personal information References

The effects of nitric oxide on striatal serotoninergic transmission involve multiple targets: an in vivo microdialysis study in the awake rat

2004

Abstract The role of endogenous nitric oxide (NO) in N -methyl- d -aspartate (NMDA)-induced modulation of serotonin (5-HT) release in the striatum of freely moving rats has been studied using microdialysis technique. NMDA-induced increase in 5-HT release was significantly inhibited by selective nitric oxide synthase (nNOS) inhibitor S -methylthiocitrulline (S-Me-TC), ONOO − scavenger l -cysteine ( l -cys), and guanylate cyclase (GC) inhibitor 1 H [1,2,4]oxadiazolo[4,3- a ]quinoxalin-1-one (ODQ). These data suggest that modulation of 5-HT levels is linked to the formation of NO produced by NMDA receptor activation and that endogenously produced NO increases 5-HT concentrations both by stimul…